Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein.

@article{Golts2002MagnesiumIS,
  title={Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein.},
  author={Natalie Golts and Heather N. Snyder and Mark Frasier and Catherine M Theisler and Peter Byonghyock Choi and Benjamin Wolozin},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 18},
  pages={
          16116-23
        }
}
Multiple studies implicate metals in the pathophysiology of neurodegenerative diseases. Disturbances in brain iron metabolism are linked with synucleinopathies. For example, in Parkinson's disease, iron levels are increased and magnesium levels are reduced in the brains of patients. To understand how changes in iron and magnesium might affect the pathophysiology of Parkinson's disease, we investigated binding of iron to alpha-synuclein, which accumulates in Lewy bodies. Using fluorescence of… CONTINUE READING

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