Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen.

  title={Magnesium inhibits nickel-induced genotoxicity and formation of reactive oxygen.},
  author={Yong Cheol Hong and Seung R Paik and Hong Jin Lee and Kwang Hyuck Lee and Sun Mi Jang},
  journal={Environmental Health Perspectives},
  pages={744 - 748}
Nickel compounds are recognized to cause nasal and lung cancers. Magnesium is an effective protector against nickel-induced carcinogenesis in vivo, although its mechanisms of protection remain elusive. The effects of magnesium carbonate on the cytotoxicity and genotoxicity induced by nickel subsulfide were examined with respect to the inhibition of cell proliferation, micronuclei formation, DNA-protein cross-link formation, and intranuclear nickel concentration. The generation of reactive… CONTINUE READING


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