• Corpus ID: 30503883

Magnesium inhibition of carbachol-induced contractions of the rat uterus and gastrointestinal tract: ex vivo effect of long term streptozotocin-induced diabetes.

@article{Hemmings1993MagnesiumIO,
  title={Magnesium inhibition of carbachol-induced contractions of the rat uterus and gastrointestinal tract: ex vivo effect of long term streptozotocin-induced diabetes.},
  author={F J Hemmings and J Rai and Cheryl Padgham and Nicholas J. Birch},
  journal={Magnesium research},
  year={1993},
  volume={6 4},
  pages={
          343-8
        }
}
Rats were rendered diabetic by a single administration of streptozotocin (STZ). They were maintained in the diabetic state for six weeks before being killed, and diabetic state was confirmed by routine urine and blood glucose estimations. The contractile sensitivity of jejunum, colon, stomach fundus and uterus to carbachol was reduced in control animals by increasing buffer magnesium concentration from 1.9 mmol/litre to 23.8 mmol/litre. This magnesium effect was reversed in the colon, stomach… 

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