Magnesium improves cisplatin-mediated tumor killing while protecting against cisplatin-induced nephrotoxicity.


Approximately 30% of all cancer patients treated with cisplatin, a widely used broad-spectrum chemotherapeutic agent, experience acute kidney injury (AKI). Almost all patients receiving cisplatin have magnesium (Mg) losses, which are proposed to aggravate AKI. Currently, there are no methods to successfully treat or prevent cisplatin-AKI. Whereas Mg… (More)
DOI: 10.1152/ajprenal.00688.2016