Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial.

@article{Muir2004MagnesiumFA,
  title={Magnesium for acute stroke (Intravenous Magnesium Efficacy in Stroke trial): randomised controlled trial.},
  author={Keith Muir and Kennedy R. Lees and Ian Ford Ford and Stephen Davis},
  journal={Lancet},
  year={2004},
  volume={363 9407},
  pages={439-45}
}
BACKGROUND Magnesium is neuroprotective in animal models of stroke, and findings of small clinical pilot trials suggest potential benefit in people. We aimed to test whether intravenous magnesium sulphate, given within 12 h of stroke onset, reduces death or disability at 90 days. METHODS 2589 patients were randomised within 12h of acute stroke to receive 16 mmol MgSO4 intravenously over 15 min and then 65 mmol over 24 h, or matching placebo. Primary outcome was a global endpoint statistic… CONTINUE READING
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