Magnesium-dependent RNA binding to the PA endonuclease domain of the avian influenza polymerase.

Abstract

Influenza A viruses are highly pathogenic and pose an unpredictable public health danger to humans. An attractive target for developing new antiviral drugs is the PA N-terminal domain (PAN) of influenza polymerase, which is responsible for the endonuclease activity and essential for viral replication. Recently, the crystal structures of the holo form of PAN… (More)
DOI: 10.1021/jp408383g

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