Magnesium deficiency upregulates sphingomyelinases in cardiovascular tissues and cells: cross-talk among proto-oncogenes, Mg(2+), NF-κB and ceramide and their potential relationships to resistant hypertension, atherogenesis and cardiac failure.

@article{Altura2013MagnesiumDU,
  title={Magnesium deficiency upregulates sphingomyelinases in cardiovascular tissues and cells: cross-talk among proto-oncogenes, Mg(2+), NF-κB and ceramide and their potential relationships to resistant hypertension, atherogenesis and cardiac failure.},
  author={Burton M. Altura and Nilank C. Shah and Gatha J. Shah and Wenyan Li and A Ping Zhang and Tao Zheng and Zhiqiang Li and Xian-cheng Jiang and Jos{\'e} Luis Perez-Albela and Bella T. Altura},
  journal={International journal of clinical and experimental medicine},
  year={2013},
  volume={6 10},
  pages={861-79}
}
The present study tested the hypotheses that 1) short-term (ST) dietary deficiency of magnesium (MgD; 21 days) in rats would result in the upregulation of neutral-, acid-, and alkaline- sphingomyelinases SMases) in cardiac and vascular smooth muscles (VSMCs), 2) ST MgD would result in an upregulation of proto-oncogenes, i.e., c-Fos and c-Jun, as well as the… CONTINUE READING