Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c.

@article{Altura2010MagnesiumDU,
  title={Magnesium deficiency upregulates serine palmitoyl transferase (SPT 1 and SPT 2) in cardiovascular tissues: relationship to serum ionized Mg and cytochrome c.},
  author={B. Mauricio Altura and Nilank C. Shah and Zhiqiang Li and Xian-cheng Jiang and Jos{\'e} Luis Perez-Albela and Bella T. Altura},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2010},
  volume={299 3},
  pages={
          H932-8
        }
}
The present work tested the hypothesis that a short-term dietary deficiency of magnesium (Mg) (21 days) in rats would result in the upregulation of the two major subunits of serine palmitoyl-CoA-transferase, serine palmitoyl transferase (SPT 1) and SPT 2 (the rate-limiting enzymes responsible for the de novo biosynthesis of ceramides) in left ventricular, right ventricular, and atrial heart muscle and abdominal aortic smooth muscle, as well as induce a reduction in serum sphingomyelin… CONTINUE READING

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