Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.

@article{Oyanagi2006MagnesiumDO,
  title={Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.},
  author={Kiyomitsu Oyanagi and Emiko Kawakami and Kae Kikuchi-Horie and Kazuhiko Ohara and Kentaro Ogata and Sachiko Takahama and Manabu Wada and Tameko Kihira and Masayuki Yasui},
  journal={Neuropathology : official journal of the Japanese Society of Neuropathology},
  year={2006},
  volume={26 2},
  pages={
          115-28
        }
}
Parkinsonism-dementia complex (PDC) and amyotrophic lateral sclerosis (ALS) are fatal neurological diseases. The incidence on Guam was very high between 1950 and 1965 but decreased dramatically after 1965. It is thought that drinking water containing low levels of calcium (Ca) and magnesium (Mg), and high levels of aluminum and of a plant excitatory neurotoxin are involved in the pathogenesis of these diseases. The present experiment was performed in rats that were exposed to low Ca and/or Mg… CONTINUE READING

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