Magnesium-deficiency-enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade.

@article{Kramer1997MagnesiumdeficiencyenhancedPM,
  title={Magnesium-deficiency-enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade.},
  author={Jay H. Kramer and Terry M Phillips and William B. Weglicki},
  journal={Journal of molecular and cellular cardiology},
  year={1997},
  volume={29 1},
  pages={
          97-110
        }
}
Dietary Mg-deficiency increases the susceptibility of rat hearts to ischemia-reperfusion (I-R) injury in vitro, and also promotes substance P-associated neurogenic inflammation in vivo. The relationship between Mg-deficiency-induced neurogenic inflammation and the subsequently-enhanced free radical-mediated oxidative and functional injury during I-R was examined using the substance P receptor antagonist, L-703,606. Rats maintained on 3-week Mg-deficient (MgD; <1.8 mmol Mg/kg food) or Mg… CONTINUE READING

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