Magnesium and depression.

@article{Serefko2016MagnesiumAD,
  title={Magnesium and depression.},
  author={Anna Serefko and Aleksandra Szopa and Ewa Poleszak},
  journal={Magnesium research},
  year={2016},
  volume={29 3},
  pages={
          112-119
        }
}
Magnesium is one of the most important elements in the human body and is involved in a number of biochemical processes crucial for the proper functioning of the cardiovascular, alimentary, endocrine, and osteoarticular systems. It also plays a vital modulatory role in brain biochemistry, influencing several neurotransmission pathways associated with the development of depression. Personality changes, including apathy, depression, agitation, confusion, anxiety, and delirium are observed when… 

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References

SHOWING 1-10 OF 59 REFERENCES
THE THERAPEUTIC ROLE OF MAGNESIUM IN DIFFERENT DEPRESSIVE SYNDROMES OF FEMALE PATIENTS
TLDR
The finding that magnesium supplements can reduce the signs and symptoms of depression is based on the finding that the female subjects who were diagnosed with clinical depression and premenstrual dysphoric disorder responded positively to the magnesium therapy with elevation of mood, relaxation and sleep duration.
Magnesium intake is not related to depression risk in Spanish university graduates.
TLDR
The findings do not suggest an inverse association between magnesium intake and depressive disorder, and results were robust through different sensitivity analyses, including nutrient density or residual models.
Serum trace elements in animal models and human depression: Part III. Magnesium. Relationship with copper
TLDR
A significant positive correlation between serum magnesium/copper ratio and the severity of depression indicates a clear relationship between alterations of the homeostasis of these two ions in human depression.
Implications of Magnesium Deficiency in Type 2 Diabetes: A Review
TLDR
The present review discusses the implications of magnesium deficiency in type 2 diabetes and the role it plays in insulin secretion, binding, and activity.
Evolution of blood magnesium, sodium and potassium in depressed patients followed for three months.
TLDR
It is confirmed in this study that drug-free depressed patients have higher erythrocyte and plasma magnesium than controls, as shown in previous reports.
Magnesium Intake and Depression in Adults
TLDR
A significant association between very low magnesium intake and depression is found, especially in younger adults, and the finding of the potential protective effect ofLow magnesium intake in older adults is surprising and warrants further investigation.
...
...