Magnesium VitB6 Intake Reduces Central Nervous System Hyperexcitability in Children

  title={Magnesium VitB6 Intake Reduces Central Nervous System Hyperexcitability in Children},
  author={Marianne Mousain-Bosc and M Roche and Jean Robert Rapin and Jean Pierre Bali},
  journal={Journal of the American College of Nutrition},
  pages={545S - 548S}
Objective: Ionic magnesium (Mg2+) depletion has long been known to cause hyperexcitability with convulsive seizures in rodents, effects that have been reversed by treatment with magnesium (Mg). Metabolic disorders and genetic alterations are suspected in this pathology, in which Mg2+ transport and intracellular distribution may be reduced without change in serum Mg2+ concentrations. We evaluated the effects of Mg2+/vitamin B6 regimen on the behavior of 52 hyperexcitable children (under 15 years… 

L-Threonic Acid Magnesium Salt Supplementation in ADHD: An Open-Label Pilot Study

LTAMS supplementation was found to be effective and well tolerated and support the need to further evaluate this compound in larger samples under double-blind conditions.

Magnesium in depression.

The Efficacy of Magnesium Supplementation in Children With Attention Deficit Hyperactivity Disorder under Treatment With Methylphenidate: A Randomized Controlled Trial

The effect of magnesium supplementation alone as an adjunct to methylphenidate was very limited and there was no article that had the same dose and duration of supplementation as this study.

Magnesium in the Central Nervous System: Magnesium, hyperactivity and autism in children

Data from clinical and biological studies of Mg-vitamin B6 supplementation in attention deficit/hyperactivity disorder (ADHD) and autism (autistic spectrum disorders family, ASD) in children support the need for a controlled study to confirm or invalidate assumptions.

Magnesium in Prevention and Therapy

Low levels of magnesium have been associated with a number of chronic diseases, such as Alzheimer’s disease, insulin resistance and type-2 diabetes mellitus, hypertension, cardiovascular disease, migraine headaches, and attention deficit hyperactivity disorder (ADHD).

Systematic Review: A Systematic Review of Magnesium Therapy for Treating Attention Deficit Hyperactivity Disorder

  • Biology, Psychology
  • 2013
Patients with ADHD do not tolerate stimulants which are widely used for treating ADHD and some patients are unresponsive to medications.

SLC41A1, SLC41A3 and CNNM2: Magnesium responsive genes with potential involvement in human ailments

It is demonstrated that the substitution p.A350V potentially associated with PD is a gain-of-function mutation that enhances a core function of SLC41A1, namely Na-dependent Mg efflux by 69610% under experimental conditions, which might result in chronic intracellular Mg-deficiency.

Metabolic correction for attention deficit/hyperactivity disorder: A biochemical-physiological therapeutic approach

Objective: This investigation was undertaken to determine the reference values of specific biochemical markers that have been have been associated with behavior typical of ADHD in a group of patients

Rapid recovery from major depression using magnesium treatment.




Protective role of magnesium in cardiovascular diseases: A review

Mg2+ supplemented K+ cardioplegia modulates Ca2+ accumulation and is directly involved in the mechanisms leading to enhanced post ischemic functional recovery in the aged myocardium following ischemia, and the beneficial effects related to consequences of Mg2- supplementation are apparent.

Increased activity of the Mg2+/Na+ exchanger in red blood cells from essential hypertensive patients.

A positive correlation between diastolic blood pressure values and Mg2+/Na+ exchanger was found in the sample of essential hypertensive patients and was inversely correlated with basal intraerythrocyte M g2+ content.

The effects of magnesium physiological supplementation on hyperactivity in children with attention deficit hyperactivity disorder (ADHD). Positive response to magnesium oral loading test.

In the group of children given 6 months of magnesium supplementation, independently of other mental disorders coexisting with hyperactivity, an increase in magnesium contents in hair and a significant decrease of hyperactivity has been achieved, compared to their clinical state before supplementation and compared to the control group which had not been treated with magnesium.

Magnesium Deficiency-Dependent Audiogenic Seizures (MDDASs) in Adult Mice: A Nutritional Model for Discriminatory Screening of Anticonvulsant Drugs and Original Assessment of Neuroprotection Properties

Compared with several classic seizure tests, the nutritional MDDAS model responded to low doses of prototype antiepileptic drugs (AEDs), including phenytoinergic (PHT), carbamazepine (CBZ), phenobarbital (PB), valproic acid (VPA), ethosuximide (ESM), and diazepam (DZP), and the original neuroprotective behavior of WEB2170 was supported.

Increased Activity of the Mg/Na Exchanger in Red Blood Cells From Essential Hypertensive Patients

It is concluded that erythrocyte Mg/Na exchanger is altered in 45% of essential hypertensive patients, and this alteration could be responsible for the low basal intraery Throttle Mg content observed in essential hypertension.

Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family

Findings indicate that TRPM6 is crucial for magnesium homeostasis and implicate a TRPM family member in human disease, and are associated with autosomal-recessive hypomagnesemia with secondary hypocalcemia.

Assessment of magnesium levels in children with attention deficit hyperactivity disorder (ADHD).

The conclusion from the investigations is that magnesium deficiency in children with ADHD occurs more frequently than in healthy children.

Novel treatments for attention-deficit/hyperactivity disorder in children.

Atomoxetine, which is being developed for ADHD, reduces symptoms of ADHD without exacerbating comorbid conditions and is associated with only minor side effects, including subtle changes in blood pressure and heart rate.

Dopamine D4 gene 7-repeat allele and attention deficit hyperactivity disorder.

OBJECTIVE Family, twin, and adoption studies show attention deficit hyperactivity disorder (ADHD) to have a substantial genetic component, and some studies have reported an association between ADHD

About the misdiagnostics of magnesium deficiency

  • In Xth International Magnesium Symposium, Cairns (Australia),
  • 2003