Magnesium Regulates the Circadian Oscillator in Cyanobacteria

  title={Magnesium Regulates the Circadian Oscillator in Cyanobacteria},
  author={Young M. Jeong and Cristiano L. Dias and Casey O. Diekman and Helene Brochon and Pyonghwa Kim and Manpreet Kaur and Yong-Sung Kim and Hye-In Jang and Yong-Ick Kim},
  journal={Journal of Biological Rhythms},
  pages={380 - 390}
The circadian clock controls 24-h biological rhythms in our body, influencing many time-related activities such as sleep and wake. The simplest circadian clock is found in cyanobacteria, with the proteins KaiA, KaiB, and KaiC generating a self-sustained circadian oscillation of KaiC phosphorylation and dephosphorylation. KaiA activates KaiC phosphorylation by binding the A-loop of KaiC, while KaiB attenuates the phosphorylation by sequestering KaiA from the A-loop. Structural analysis revealed… Expand
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