Magnesium Metabolism: A Review

  title={Magnesium Metabolism: A Review},
  author={Hans Ebel and Theodor G{\"u}nther},
  booktitle={Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie},
The main literature concerning the physiology and biochemistry as well as the pathophysiology and pathobiochemistry of magnesium is reviewed, including: Distribution and physico-chemical state of magnesium in the extracellular and intracellular fluid as well as in the subcellular organelles (membranes, mitochondria, microsomes, ribosomes). Intestinal resorption, transport across membranes and excretion by the kidney. Hormonal regulation of magnesium distribution and its clinical disturbances… 

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Magnesium: metabolism and hormonal regulation in different species.
Magnesium Balance and Measurement.
A discussion as to where magnesium is stored, handled, absorbed, and excreted is provided and approaches for the assessment of magnesium status are discussed.
Magnesium metabolism and perturbations in the elderly
Because magnesium plays important roles in arterial structure and function by maintaining endothelial and platelet integrity, a deficiency can increase progression of arteriosclerosis, hypertension, and cardiac complications, including dysryhthmias.
The rationale of magnesium supplementation in acute myocardial infarction. A review of the literature.
Experiments in animals and humans have shown that the acute as well as the chronic reduction in extracellular magnesium levels are harmful to the myocardium in the setting of acute ischemia.
Magnesium and depression.
It seems that magnesium supplementation is well-tolerated and enhances the efficacy of conventional antidepressant treatments, and as such could be a valuable addition to the standard treatments for depression, although differences in bioavailability between inorganic and organic compounds should be taken into consideration.
Magnesium in man: implications for health and disease.
An extensive and comprehensive overview of Mg(2+) research over the last few decades is provided, focusing on the regulation of M g(2+) homeostasis in the intestine, kidney, and bone and disturbances which may result in hypomagnesemia.
Magnesium and insulin-dependent diabetes mellitus.
Genetics of Magnesium Disorders
Understanding rare and genetic diseases of Mg2+ dysregulation has expanded knowledge and furthers the development of strategies for preventing and managing dysmagnesemia.
Environmental Magnesium Deficiency as a Cardiovascular Risk Factor
Several studies suggest that a low level of magnesium in drinking water is a risk factor for myocardial infarction, particularly among men.
Magnesium degradation products: effects on tissue and human metabolism.
A multitude of general tissue effects and responses from the Mg's degradation products is considered within this review, which is not targeting specific implant classes.


Vitamin D and magnesium absorption in man.
It is suggested that the slight effect of vitamin D on magnesium absorption may be incidental to its stimulation of active calcium transport, since the latter system has weak affinities for other alkaline earth ions including strontium, barium and magnesium.
In vivo transport of magnesium and other cations across the wall of the gastro‐intestinal tract of sheep
The present work was carried out not only to verify the principal site of net magnesium absorption but also to investigate the mechanism by which this absorption takes place, in view of the evidence that there may be a common transport system for magnesium and calcium.
The effects of synthetic human and salmon calcitonins on electrolyte excretion in the rat.
Larger doses of salmon calcitonin produced less depression of calcium and magnesium excretion even in the presence of a greater fall in plasma calcium, and small doses of both hormones decreased urinarycium and magnesium.
The effect of glucose on urinary cation excretion during chronic extracellular volume expansion in normal man.
It is proposed that the availability of glucose in the proximal tubule stimulates Na re absorption while delaying development of a chloride diffusion potential, thereby inhibiting tubular reabsorption of Ca and Mg.
Activation and Inhibition of the Mg-Ca-ATPase from E. coli by Mg2+ and Ca2+
The real Km of the Mg-Ca-ATPase is smaller than reported in the literature because H+ competes with Mg2+ or Ca2+ for the metal binding sites.
Hypomagnesemia with tetany in nontropical sprue.
A number of reports have appeared recently describing the clinical manifestations of magnesium deficiency, and the use of simpler and more reliable methods for its estimation is suggested.
Habilitationsschrift, Freie Universität Berlin
  • 1965