Magnesium Metabolism: A Review

  title={Magnesium Metabolism: A Review},
  author={H. Ebel and T. G{\"u}nther},
  booktitle={Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie},
The main literature concerning the physiology and biochemistry as well as the pathophysiology and pathobiochemistry of magnesium is reviewed, including: Distribution and physico-chemical state of magnesium in the extracellular and intracellular fluid as well as in the subcellular organelles (membranes, mitochondria, microsomes, ribosomes). Intestinal resorption, transport across membranes and excretion by the kidney. Hormonal regulation of magnesium distribution and its clinical disturbances… Expand
Magnesium: metabolism and hormonal regulation in different species.
  • O. Ferment, Y. Touitou
  • Biology, Medicine
  • Comparative biochemistry and physiology. A, Comparative physiology
  • 1985
The kidney is the principal site of magnesium excretion and shows important magnesium regulation mechanisms, and magnesium shows analogies with calcium for intestinal absorption, renal metabolism, bone accretion and resorption. Expand
Magnesium Balance and Measurement.
A discussion as to where magnesium is stored, handled, absorbed, and excreted is provided and approaches for the assessment of magnesium status are discussed. Expand
Magnesium metabolism and perturbations in the elderly
Because magnesium plays important roles in arterial structure and function by maintaining endothelial and platelet integrity, a deficiency can increase progression of arteriosclerosis, hypertension, and cardiac complications, including dysryhthmias. Expand
The rationale of magnesium supplementation in acute myocardial infarction. A review of the literature.
Experiments in animals and humans have shown that the acute as well as the chronic reduction in extracellular magnesium levels are harmful to the myocardium in the setting of acute ischemia. Expand
Magnesium and Traumatic Brain Injury
The role of magnesium in secondary injury following traumatic brain injury (TBI) and also the efficacy of the experimental and clinical administration of magnesium as a novel therapeutic for the treatment of TBI are reviewed. Expand
Magnesium and Alzheimer’s Disease
In vitro and in vivo data indicate a role for magnesium (Mg) in many biological and clinical aspects of Alzheimer’s disease, and Mg was shown to have a role in the processing of amyloid-beta precursor protein, which plays a central roles in the pathogenesis of AD. Expand
Magnesium and depression.
It seems that magnesium supplementation is well-tolerated and enhances the efficacy of conventional antidepressant treatments, and as such could be a valuable addition to the standard treatments for depression, although differences in bioavailability between inorganic and organic compounds should be taken into consideration. Expand
Chapter 54 – Magnesium and Alzheimer’s Disease: Implications for Diet and Nutrition
Environmental factors, including nutrition and metal elements, are implicated in the pathophysiology of Alzheimer’s disease (AD). Several in vitro and in vivo data indicate a role for magnesium (Mg)Expand
Magnesium and insulin-dependent diabetes mellitus.
Appropriate magnesium supplementation might prove beneficial in normalizing the low plasma and tissue magnesium levels and prevent or retard the development of vascular complications in diabetic patients, however, well designed and documented experiments need to be performed before the rationales for such therapy are well established. Expand
Magnesium in man: implications for health and disease.
An extensive and comprehensive overview of Mg(2+) research over the last few decades is provided, focusing on the regulation of M g(2+) homeostasis in the intestine, kidney, and bone and disturbances which may result in hypomagnesemia. Expand


Vitamin D and magnesium absorption in man.
It is suggested that the slight effect of vitamin D on magnesium absorption may be incidental to its stimulation of active calcium transport, since the latter system has weak affinities for other alkaline earth ions including strontium, barium and magnesium. Expand
In vivo transport of magnesium and other cations across the wall of the gastro‐intestinal tract of sheep
The present work was carried out not only to verify the principal site of net magnesium absorption but also to investigate the mechanism by which this absorption takes place, in view of the evidence that there may be a common transport system for magnesium and calcium. Expand
The effects of synthetic human and salmon calcitonins on electrolyte excretion in the rat.
Larger doses of salmon calcitonin produced less depression of calcium and magnesium excretion even in the presence of a greater fall in plasma calcium, and small doses of both hormones decreased urinarycium and magnesium. Expand
The effect of glucose on urinary cation excretion during chronic extracellular volume expansion in normal man.
It is proposed that the availability of glucose in the proximal tubule stimulates Na re absorption while delaying development of a chloride diffusion potential, thereby inhibiting tubular reabsorption of Ca and Mg. Expand
Activation and Inhibition of the Mg-Ca-ATPase from E. coli by Mg2+ and Ca2+
The real Km of the Mg-Ca-ATPase is smaller than reported in the literature because H+ competes with Mg2+ or Ca2+ for the metal binding sites. Expand
Hypomagnesemia with tetany in nontropical sprue.
A number of reports have appeared recently describing the clinical manifestations of magnesium deficiency, and the use of simpler and more reliable methods for its estimation is suggested. Expand
Habilitationsschrift, Freie Universität Berlin
  • 1965
Ebel and Günther: Magnesium metabolism
  • Exp. Cell. Res
  • 1980