Magnesium Homeostasis and Clinical Disorders of Magnesium Deficiency

@article{Whang1994MagnesiumHA,
  title={Magnesium Homeostasis and Clinical Disorders of Magnesium Deficiency},
  author={Robert Whang and Edward M. Hampton and David D. Whang},
  journal={Annals of Pharmacotherapy},
  year={1994},
  volume={28},
  pages={220 - 226}
}
OBJECTIVE: To survey the causes of clinical hypomagnesemia and Mg deficiency. The relationship of hypomagnesemia to digitalis toxicity, congestive heart failure, arrhythmias, and acute myocardial infarction is discussed, as is the clinical interrelationship of Mg and K concentrations, the principal intracellular cations. DATA SOURCES: A MEDLINE search and retrieval was used to identify relevant references. STUDY SELECTION: Clinical reports, as well as studies, were selected for this review… 

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Routine serum Mg determination would facilitate identification of hypomagnesemia which may be a more frequent contributor to digitalis toxicity than hypokalemia and identification and treatment of patients at risk for refractory K repletion would be facilitated by routine serum MG determination.

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Therapy of Mg deficiency in the presence of renal insufficiency requires smaller doses and frequent monitoring, and complete repletion occurs slowly.

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This work plans to present various methods of treating overt and occult magnesium deficiency, and recommends a relatively simple Titan yellow method for monitoring plasma levels in a hospital where more precise but complex methods are not available.

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Hypermagnesemia, which usually results from magnesium overdosage or inadequate renal function, is a potential threat to neonates born to magnesium-treated eclamptic mothers, but obtunded neonates may require dialysis.
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