Magnesium Excretion in C. elegans Requires the Activity of the GTL-2 TRPM Channel

@inproceedings{Teramoto2010MagnesiumEI,
  title={Magnesium Excretion in C. elegans Requires the Activity of the GTL-2 TRPM Channel},
  author={Takayuki Teramoto and Laura A. Sternick and Eriko Kage-Nakadai and Shirine Sajjadi and Jakub Siembida and Shohei Mitani and Kouichi Iwasaki and Eric J Lambie},
  booktitle={PloS one},
  year={2010}
}
Systemic magnesium homeostasis in mammals is primarily governed by the activities of the TRPM6 and TRPM7 cation channels, which mediate both uptake by the intestinal epithelial cells and reabsorption by the distal convoluted tubule cells in the kidney. In the nematode, C. elegans, intestinal magnesium uptake is dependent on the activities of the TRPM channel proteins, GON-2 and GTL-1. In this paper we provide evidence that another member of the TRPM protein family, GTL-2, acts within the C… CONTINUE READING

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