Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

@article{Roth2004MagicSV,
  title={Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia},
  author={Bryan L. Roth and Douglas J. Sheffler and Wesley K. Kroeze},
  journal={Nature Reviews Drug Discovery},
  year={2004},
  volume={3},
  pages={353-359}
}
Most common central nervous system disorders — such as depression, bipolar disorder and schizophrenia — seem to be polygenic in origin, and the most effective medications have exceedingly complex pharmacologies. Attempts to develop more effective treatments for diseases such as schizophrenia and depression by discovering drugs selective for single molecular targets (that is, 'magic bullets') have, not surprisingly, been largely unsuccessful. Here we propose that designing selectively non… 

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