Maf1 regulation: a model of signal transduction inside the nucleus.

  title={Maf1 regulation: a model of signal transduction inside the nucleus.},
  author={Yuehua Wei and X. F. Steven Zheng},
  volume={1 2},
RNA polymerase III (Pol III) is responsible for the synthesis of 5S ribosomal RNA (rRNA) and transfer RNAs (tRNAs) essential for protein synthesis and cell growth. Pol III is tightly controlled by growth signals such as nutrients and deregulation of Pol III-dependent transcription can lead to oncogenic transformation. In response to extracellular stimuli, the target of rapamycin complex 1 (TORC1) regulates Pol III activity through Maf1, a key conserved Pol III repressor. Recent studies have… CONTINUE READING
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