Maf1 protein, repressor of RNA polymerase III, indirectly affects tRNA processing.

@article{Karkusiewicz2011Maf1PR,
  title={Maf1 protein, repressor of RNA polymerase III, indirectly affects tRNA processing.},
  author={Iwona Karkusiewicz and Tomasz W. Turowski and Damian Graczyk and Joanna Towpik and Nripesh Dhungel and Anita K Hopper and Magdalena Boguta},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 45},
  pages={39478-88}
}
Maf1 is negative regulator of RNA polymerase III in yeast. We observed high levels of both primary transcript and end-matured, intron-containing pre-tRNAs in the maf1Δ strain. This pre-tRNA accumulation could be overcome by transcription inhibition, arguing against a direct role of Maf1 in tRNA maturation and suggesting saturation of processing machinery by the increased amounts of primary transcripts. Saturation of the tRNA exportin, Los1, is one reason why end-matured intron-containing pre… CONTINUE READING

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