Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.

Abstract

Cholesterol is a major constituent of myelin membranes, which insulate axons and allow saltatory conduction. Therefore, Schwann cells, the myelinating glia of the peripheral nervous system, need to produce large amounts of cholesterol. Here, we define a crucial role of the transcription factor Maf in myelination and cholesterol biosynthesis and show that… (More)
DOI: 10.1101/gad.310490.117

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