Mads and Smads in TGF beta signalling.

  title={Mads and Smads in TGF beta signalling.},
  author={Liliana Attisano and Jeff L. Wrana},
  journal={Current opinion in cell biology},
  volume={10 2},
The discovery of the Mothers against dpp (Mad) gene in Drosophila has opened a window on an entirely unique signalling pathway that functions to mediate responses to the tumour growth factor beta (TGF beta) superfamily. This pathway, which is comprised of a family of proteins related to Mad, acts to convey signals directly from TGF beta receptors to the nucleus and is implicated in the pathogenesis of human diseases. 

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