Madin-Darby canine kidney cells. II. Aldosterone stimulates Na+/H+ and Cl-/HCO3- exchange.

@article{Oberleithner1990MadinDarbyCK,
  title={Madin-Darby canine kidney cells. II. Aldosterone stimulates Na+/H+ and Cl-/HCO3- exchange.},
  author={Hans Oberleithner and Ulrich Vogel and Ulrich Kersting and Wieland Steigner},
  journal={Pflugers Archiv : European journal of physiology},
  year={1990},
  volume={416 5},
  pages={533-9}
}
Experiments in dome epithelium of Madin-Darby canine kidney (MDCK) cells were performed to elucidate aldosterone action on acid-base transport. By means of pH-sensitive microelectrodes the pH of the dome fluid was measured while the apical plasma membrane was superfused. In the absence of HCO3- the dome fluid (facing the basolateral cell membrane) alkalinized in response to 10(-7) mol/l aldosterone. Amiloride (10(-3) mol/l) inhibited dome formation and pH recovery of the dome fluid from an… CONTINUE READING
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