Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal

@inproceedings{Sotillo2010Mad2inducedCI,
  title={Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal},
  author={Roc{\'i}o Sotillo and Juan-Manuel Schvartzman and Nicholas D. Socci and Robert Benezra},
  booktitle={Nature},
  year={2010}
}
Inhibition of an initiating oncogene often leads to extensive tumour cell death, a phenomenon known as oncogene addiction. This has led to the search for compounds that specifically target and inhibit oncogenes as anticancer agents. However, there has been no systematic exploration of whether chromosomal instability generated as a result of deregulation of the mitotic checkpoint pathway, a frequent characteristic of solid tumours, has any effect on oncogene addiction. Here we show that… CONTINUE READING
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