Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.

@article{Orr2007Mad2independentSA,
  title={Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.},
  author={Bernardo Orr and Hassan Bousbaa and Claudio Enrique Sunkel},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 3},
  pages={
          850-63
        }
}
The spindle assembly checkpoint is essential to maintain genomic stability during cell division. We analyzed the role of the putative Drosophila Mad2 homologue in the spindle assembly checkpoint and mitotic progression. Depletion of Mad2 by RNAi from S2 cells shows that it is essential to prevent mitotic exit after spindle damage, demonstrating its… CONTINUE READING