Mad-related genes in the human

  title={Mad-related genes in the human},
  author={Gregory Joseph Riggins and Sam Thiagalingam and Ester Rozenblum and Craig L. Weinstein and Scott E. Kern and Stanley R. Hamilton and James K. V. Willson and Sanford D Markowitz and Kenneth W. Kinzler and Bert Vogelstein},
  journal={Nature Genetics},
Resistance to the growth inhibitory effects of TGF-β is common in human cancers1,2. However, the mechanism(s) by which tumour cells become resistant to TGF-β are generally unknown. We have identified five novel human genes related to a Drosophila gene called Mad which is thought to transduce signals from TGF-β family members3–5. One of these genes was found to be somatically mutated in two of eighteen colorectal cancers, and three of the other genes were located at chromosomal positions… CONTINUE READING

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