Mad Is Required for Wingless Signaling in Wing Development and Segment Patterning in Drosophila

@inproceedings{Eivers2009MadIR,
  title={Mad Is Required for Wingless Signaling in Wing Development and Segment Patterning in Drosophila},
  author={Edward Eivers and Luis C. Fuentealba and Veronika Sander and James C. Clemens and Lori Hartnett and Edward M De Robertis},
  booktitle={PloS one},
  year={2009}
}
A key question in developmental biology is how growth factor signals are integrated to generate pattern. In this study we investigated the integration of the Drosophila BMP and Wingless/GSK3 signaling pathways via phosphorylations of the transcription factor Mad. Wingless was found to regulate the phosphorylation of Mad by GSK3 in vivo. In epistatic experiments, the effects of Wingless on wing disc molecular markers (senseless, distalless and vestigial) were suppressed by depletion of Mad with… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 61 references

Extracellular modulation of BMP activity in patterning the dorsoventral axis.

Birth defects research. Part C, Embryo today : reviews • 2006
View 8 Excerpts
Highly Influenced

Early Development of Xenopus laevis: A Laboratory Manual

HL Sive, RM Grainger, RM Harland
2000
View 3 Excerpts
Highly Influenced

Gal4 in the Drosophila female germline

Mechanisms of Development • 1998
View 3 Excerpts
Highly Influenced

Ancestral Notch-mediated segmentation revealed in the cockroach Periplaneta americana.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 1 Excerpt

Asymmetric mitosis: Unequal segregation of proteins destined for degradation.

Proceedings of the National Academy of Sciences of the United States of America • 2008
View 5 Excerpts

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