Macula densa sensing and signaling mechanisms of renin release.

  title={Macula densa sensing and signaling mechanisms of renin release.},
  author={J{\'a}nos Peti-Peterdi and Raymond C Harris},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 7},
Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis. Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in… CONTINUE READING
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