Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein.

@article{Kruth2005MacropinocytosisIT,
  title={Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein.},
  author={Howard S. Kruth and Nancy L. Jones and Wei Huang and Bin Zhao and Itsuko Ishii and Janet Chang and Christian A. Combs and Daniela Malide and Wei-yang Zhang},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 3},
  pages={2352-60}
}
Previously, we reported that fluid-phase endocytosis of native LDL by PMA-activated human monocytederived macrophages converted these macrophages into cholesterol-enriched foam cells (Kruth, H. S., Huang, W., Ishii, I., and Zhang, W. Y. (2002) J. Biol. Chem. 277, 34573-34580). Uptake of fluid by cells can occur either by micropinocytosis within vesicles (<0.1 microm diameter) or by macropinocytosis within vacuoles ( approximately 0.5-5.0 microm) named macropinosomes. The current investigation… CONTINUE READING

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Macropinocytosis Mediates LDL-induced Foam Cell Formation

G. K. Hansson, P. Libby, U. Schonbeck, Z. Q. Yan
Foam Cell doi: 10.1074/jbc.M407167200 originally published online November • 2002

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