Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events

  title={Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events},
  author={S. Falcone and Emanuele Cocucci and P. Podini and T. Kirchhausen and E. Clementi and J. Meldolesi},
  journal={Journal of Cell Science},
  pages={4758 - 4769}
  • S. Falcone, Emanuele Cocucci, +3 authors J. Meldolesi
  • Published 2006
  • Medicine, Biology
  • Journal of Cell Science
  • Macropinocytosis, a form of bulk uptake of fluid and solid cargo into cytoplasmic vacuoles, called macropinosomes, has been studied mostly in relation to antigen presentation. Early membrane traffic events occurring in this process are, however, largely unknown. Using human dendritic cells we show that a marked increase in the rate of macropinocytosis occurs a few minutes after application of two markers (small latex beads or dextran), depends on a slow intracellular Ca2+ concentration ([Ca2+]i… CONTINUE READING
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