Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.

@article{Alenghat2012MacrophagesRS,
  title={Macrophages require Skap2 and Sirpα for integrin-stimulated cytoskeletal rearrangement.},
  author={Francis J. Alenghat and Quentin J. Baca and Nooreen T. Rubin and Lily I. Pao and Takashi Matozaki and Clifford A Lowell and David E. Golan and Benjamin G Neel and Kenneth D. Swanson},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 22},
  pages={5535-45}
}
Macrophages migrate to sites of insult during normal inflammatory responses. Integrins guide such migration, but the transmission of signals from integrins into the requisite cytoskeletal changes is poorly understood. We have discovered that the hematopoietic adaptor protein Skap2 is necessary for macrophage migration, chemotaxis, global actin… CONTINUE READING