Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.

@article{Vi2015MacrophagesPO,
  title={Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.},
  author={Linda Vi and Gurpreet S. Baht and Heather C Whetstone and Adeline H M Ng and Qingxia Wei and Raymond Poon and Sivakami M. Mylvaganam and Marc D. Grynpas and Benjamin A Alman},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2015},
  volume={30 6},
  pages={1090-102}
}
Macrophages are activated in inflammation and during early phases of repair processes. Interestingly, they are also present in bone during development, but their function during this process is unclear. Here, we explore the function of macrophages in bone development, growth, and repair using transgenic mice to constitutively or conditionally deplete macrophages. Depletion of macrophages led to early skeletal growth retardation and progressive osteoporosis. By 3 months of age, macrophage… CONTINUE READING
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