Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses.

@article{Aichele2003MacrophagesOT,
  title={Macrophages of the splenic marginal zone are essential for trapping of blood-borne particulate antigen but dispensable for induction of specific T cell responses.},
  author={Peter Aichele and Jana Zinke and Leander Grode and Reto Albert Schwendener and Stefan H. E. Kaufmann and Peter Seiler},
  journal={Journal of immunology},
  year={2003},
  volume={171 3},
  pages={1148-55}
}
Rapid removal of pathogens from the circulation by secondary lymphoid organs is prerequisite for successful control of infection. Blood-borne Ags are trapped mainly in the splenic marginal zone. To identify the cell populations responsible for Ag trapping in the marginal zone, mice were selectively depleted of marginal zone macrophages and marginal metallophilic macrophages. In the absence of these cells, trapping of microspheres and Listeria monocytogenes organisms was lost, and early control… CONTINUE READING