Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype

@inproceedings{Christophi2009MacrophagesOM,
  title={Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype},
  author={George P Christophi and M Pardalos Panos and Chad A. Hudson and Rebecca L. Christophi and Ross C. Gruber and Akos T. Mersich and Scott D Blystone and Burk Jubelt and Paul T. Massa},
  booktitle={Laboratory Investigation},
  year={2009}
}
Recent studies in mice have demonstrated that the protein tyrosine phosphatase SHP-1 is a crucial negative regulator of proinflammatory cytokine signaling, TLR signaling, and inflammatory gene expression. Furthermore, mice genetically lacking SHP-1 (me/me) display a profound susceptibility to inflammatory CNS demyelination relative to wild-type mice. In particular, SHP-1 deficiency may act predominantly in inflammatory macrophages to increase CNS demyelination as SHP-1-deficient macrophages… CONTINUE READING
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