Macrophages in the embryo and beyond: Much more than just giant phagocytes
@article{Ovchinnikov2008MacrophagesIT, title={Macrophages in the embryo and beyond: Much more than just giant phagocytes}, author={D. Ovchinnikov}, journal={genesis}, year={2008}, volume={46} }
Originally recognized as an essential part of the innate and acquired immune systems, macrophages emerged as omnipresent and influential regulators of embryo‐ and organo‐genesis, as well as of tissue and tumor growth. Macrophages are present essentially in all tissues, beginning with embryonic development and, in addition to their role in host defense and in the clearance of apoptotic cells, are being increasingly recognized for their trophic function and role in regeneration. Some tissue… CONTINUE READING
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References
SHOWING 1-10 OF 178 REFERENCES
Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80.
- Biology, Medicine
- Development
- 1991
- 185
- PDF
Apoptotic cell removal in development and tissue homeostasis.
- Biology, Medicine
- Trends in immunology
- 2006
- 353
Macrophages in the murine pancreas and their involvement in fetal endocrine development in vitro
- Biology, Medicine
- Journal of leukocyte biology
- 2005
- 83
Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter.
- Biology, Medicine
- Developmental biology
- 2007
- 177
- PDF
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.
- Medicine
- Critical reviews in oncology/hematology
- 2008
- 782
- PDF
Differentiation of the mononuclear phagocyte system during mouse embryogenesis: the role of transcription factor PU.1.
- Biology, Medicine
- Blood
- 1999
- 164
- PDF
Expression of Developmental Endothelial Locus-1 in a Subset of Macrophages for Engulfment of Apoptotic Cells1
- Biology, Medicine
- The Journal of Immunology
- 2004
- 124
- PDF
Ontogeny and behaviour of early macrophages in the zebrafish embryo.
- Biology, Medicine
- Development
- 1999
- 671
- PDF