Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris.

  title={Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris.},
  author={Xi Wang and Kai Cao and Xin Yu Sun and Yongxiong Chen and Zhaoxia Duan and Li Sun and Lei Guo and Paul Bai and Dongming Sun and Jianqing Fan and Xijing He and Wise Young and Yi Ren},
  volume={63 4},
Macrophage activation and persistent inflammation contribute to the pathological process of spinal cord injury (SCI). It was reported that M2 macrophages were induced at 3-7 days after SCI but M2 markers were reduced or eliminated after 1 week. By contrast, M1 macrophage response is rapidly induced and then maintained at injured spinal cord. However, factors that modulate macrophage phenotype and function are poorly understood. We developed a model to distinguish bone-marrow derived macrophages… CONTINUE READING
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  • JFJ Bogie, S Timmermans, +8 authors JJ. Hendriks
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