Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury.

@article{Chow2004MacrophagesIM,
  title={Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury.},
  author={Fiona Y F Chow and Elyce Ozols and David J Nikolic-Paterson and Robert C. Atkins and Gregory H. Tesch},
  journal={Kidney international},
  year={2004},
  volume={65 1},
  pages={116-28}
}
BACKGROUND Macrophage-mediated renal injury has been implicated in progressive forms of glomerulonephritis; however, a role for macrophages in type 2 diabetic nephropathy, the major cause of end-stage renal failure, has not been established. Therefore, we examined whether macrophages may promote the progression of type 2 diabetic nephropathy in db/db mice. METHODS The incidence of renal injury was examined in db/db mice with varying blood sugar and lipid levels at 8 months of age. The… CONTINUE READING
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