Macrophages in innate and acquired immunity.

  title={Macrophages in innate and acquired immunity.},
  author={Homer L Twigg},
  journal={Seminars in respiratory and critical care medicine},
  volume={25 1},
  • Homer L Twigg
  • Published 2004 in
    Seminars in respiratory and critical care…
Alveolar macrophages play a central role in pulmonary host defense. When foreign particles or pathogens enter the respiratory tract, constitutively present innate host defenses attempt to clear the challenge. Alveolar macrophage phagocytosis of foreign material is a critical component of this response, as is secretion of inflammatory mediators designed to combat invading pathogens. If the pathogenic burden is too large and overwhelms innate immunity, then acquired immune responses are initiated… CONTINUE READING


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