Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells.

@article{Zhou2006MacrophagesFC,
  title={Macrophages from C3-deficient mice have impaired potency to stimulate alloreactive T cells.},
  author={Wuding Zhou and Hetal Patel and Ke Li and Q. Z. Peng and Marie-Bernadette Villiers and Steven H Sacks},
  journal={Blood},
  year={2006},
  volume={107 6},
  pages={
          2461-9
        }
}
Impaired T-cell reactivity is a feature of C3-deficient mice in several disease models. The mechanism behind the reduced T-cell response is, however, poorly understood. We explored the hypothesis that antigen-presenting cells (APCs) from C3-/- mice have impaired potency to stimulate antigen-specific T cells, in an alloantigen-dependent model. Our results show that C3-/- macrophages have reduced ability to elicit alloreactive T-cell responses in vitro and in vivo, affecting both the primary and… CONTINUE READING

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