Macrophages expressing heme oxygenase-1 improve renal function in ischemia/reperfusion injury.


Acute kidney injury has a high mortality and lacks specific therapies, with ischemia/reperfusion injury (IRI) being the predominant cause. Macrophages (M phi) have been used successfully in cell therapy to deliver targeted therapeutic genes in models of inflammatory kidney disease. Heme oxygenase-1 (HO-1) catalyzes heme breakdown and has important… (More)
DOI: 10.1038/mt.2010.100


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