Macrophages express membrane bound form of APRIL that can generate immunomodulatory signals.

@article{Lee2010MacrophagesEM,
  title={Macrophages express membrane bound form of APRIL that can generate immunomodulatory signals.},
  author={S R Lee and Sung-Tak Jeon and Kyoungho Suk and W H Lee},
  journal={Immunology},
  year={2010},
  volume={131 3},
  pages={350-6}
}
Members of the tumour necrosis factor superfamily play an essential role in inducing various biological responses including proliferation, differentiation, survival and cell death. A proliferation-inducing ligand (APRIL), first identified as a stimulant of tumour proliferation, is now known as a regulator of B-cell-mediated immune responses through the modulation of B-cell survival and activation. However, the role of APRIL in macrophage function has not been explored. High level expression of… CONTINUE READING
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