Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury.

@article{Ko2008MacrophagesCT,
  title={Macrophages contribute to the development of renal fibrosis following ischaemia/reperfusion-induced acute kidney injury.},
  author={Gang Jee Ko and Chang-Su Boo and Sang Kyung Jo and Wonyong Cho and Hyoung Kyu Kim},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2008},
  volume={23 3},
  pages={842-52}
}
BACKGROUND Ischaemia/reperfusion is a major cause of acute kidney injury and can result in poor long-term graft function. Although most of the patients with acute kidney injury recover their renal function, significant portion of patients suffer from progressive deterioration of renal function. A persistent inflammatory response might be associated with long-term changes following acute ischaemia/reperfusion. Macrophages are known to infiltrate into tubulointersitium in animal models of chronic… CONTINUE READING
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