Macrophages as a source of tumoricidal activity (tumor-necrotizing factor).

  title={Macrophages as a source of tumoricidal activity (tumor-necrotizing factor).},
  author={Daniela N M{\"a}nnel and Robert N. Moore and Stephan E. Mergenhagen},
  journal={Infection and immunity},
  volume={30 2},
Macrophage-enriched peritoneal exudate cells from mice infected with Mycobacterium bovis BCG, macrophage-like tumor cells (PU 5-1.8), and peritoneal macrophages propagated in vitro with macrophage growth factor released tumoricidal activity into the culture medium within 2 to 3 h after stimulation with nanogram quantities of bacterial lipopolysaccharide. The cytotoxic activities from each of the macrophage culture supernatants eluted from diethylaminoethyl-Sephacel columns at a sodium chloride… CONTINUE READING


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Functional characterization of a stable , noncytolytic stage of macrophage activation in tumors

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