Macrophages are required for adult salamander limb regeneration.

  title={Macrophages are required for adult salamander limb regeneration.},
  author={James W. Godwin and Alexander Ruvantha Pinto and Nadia A. Rosenthal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 23},
The failure to replace damaged body parts in adult mammals results from a muted growth response and fibrotic scarring. Although infiltrating immune cells play a major role in determining the variable outcome of mammalian wound repair, little is known about the modulation of immune cell signaling in efficiently regenerating species such as the salamander, which can regrow complete body structures as adults. Here we present a comprehensive analysis of immune signaling during limb regeneration in… CONTINUE READING
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