Macrophages are not the source of injurious interleukin-18 in ischemic acute kidney injury in mice.

Abstract

We previously reported in ischemic acute kidney injury (AKI) in mice that caspase-1-mediated production of interleukin-18 (IL-18) is pathogenic and that macrophage depletion by liposome-encapsulated clodronate (LEC) is protective. Therefore, our aim was to determine whether macrophages are a source of IL-18 in ischemic AKI in mice. On immunofluorescence… (More)
DOI: 10.1152/ajprenal.90634.2008

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