Macrophages are critical effectors of antibody therapies for cancer.

  title={Macrophages are critical effectors of antibody therapies for cancer.},
  author={Kipp Weiskopf and Irving L Weissman},
  volume={7 2},
Macrophages are innate immune cells that derive from circulating monocytes, reside in all tissues, and participate in many states of pathology. Macrophages play a dichotomous role in cancer, where they promote tumor growth but also serve as critical immune effectors of therapeutic antibodies. Macrophages express all classes of Fcγ receptors, and they have immense potential to destroy tumors via the process of antibody-dependent phagocytosis. A number of studies have demonstrated that macrophage… CONTINUE READING