Macrophages and the pathogenesis of COPD.

  title={Macrophages and the pathogenesis of COPD.},
  author={Teresa D. Tetley},
  volume={121 5 Suppl},
Macrophages are long-lived effector cells within the lung. They are reactive, responding to endogenous and exogenous stimuli, as well as proactive, producing mediators that modulate the behavior of surrounding cells. In addition, they play a critical role in the clearance of apoptotic neutrophils. Their role in COPD probably reflects a number of functional properties. However, if the link between increased proteinase burden and tissue destruction and injury in patients with COPD is correct… CONTINUE READING


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