Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy.

@article{Tuckermann2007MacrophagesAN,
  title={Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy.},
  author={Jan P Tuckermann and Anna Kleiman and Richard Moriggl and Rainer Spanbroek and Anita Neumann and Anett Illing and Bj{\"o}rn E Clausen and Brenda D. Stride and Irmgard Foerster and Andreas J. R. Habenicht and Holger M. Reichardt and François Tronche and Wolfgang P. Schmid and G. Sch{\"u}tz},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 5},
  pages={
          1381-90
        }
}
Glucocorticoids (GCs) are widely used in the treatment of allergic skin conditions despite having numerous side effects. Here we use Cre/loxP-engineered tissue- and cell-specific and function-selective GC receptor (GR) mutant mice to identify responsive cell types and molecular mechanisms underlying the antiinflammatory activity of GCs in contact hypersensitivity (CHS). CHS was repressed by GCs only at the challenge phase, i.e., during reexposure to the hapten. Inactivation of the GR gene in… CONTINUE READING

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