Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis.

@article{Giusti2015MacrophagesAG,
  title={Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis.},
  author={Carolina Jaquenod de Giusti and Agust{\'i}n Enrique Ure and Leonardo Rivadeneyra and Mirta Schattner and Ricardo M G{\'o}mez},
  journal={Journal of molecular and cellular cardiology},
  year={2015},
  volume={85},
  pages={
          58-70
        }
}
Macrophage influx and galectin 3 production have been suggested as major players driving acute inflammation and chronic fibrosis in many diseases. However, their involvement in the pathogenesis of viral myocarditis and subsequent cardiomyopathy are unknown. Our aim was to characterise the role of macrophages and galectin 3 on survival, clinical course, viral burden, acute pathology, and chronic fibrosis in coxsackievirus B3 (CVB3)-induced myocarditis. Our results showed that C3H/HeJ mice… CONTINUE READING
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