Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis.

@article{Zhang2016MacrophagesAI,
  title={Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis.},
  author={Guannan Zhang and Xue Li and Chengyu Sheng and X Chen and Yu Chen and Dingliang L Zhu and Ping-jin Gao},
  journal={Nitric oxide : biology and chemistry},
  year={2016},
  volume={61},
  pages={20-28}
}
A large amount of NO is generated through the inducible nitric oxide synthase (iNOS) pathway from the vascular adventitia in various vascular diseases. However, it is currently not fully understood how the iNOS signaling pathway is activated. In the present study, this question was addressed in the context of adventitial cellular interactions. A rat model of acute hypertension in the contralateral carotid arteries was established through transverse aortic constriction (TAC) surgery. In this… CONTINUE READING
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