Macrophages acquire fibroblast characteristics in a rat model of proliferative vitreoretinopathy.

@article{Lin2011MacrophagesAF,
  title={Macrophages acquire fibroblast characteristics in a rat model of proliferative vitreoretinopathy.},
  author={Miao-li Lin and Yong-ping Li and Zhan-rong Li and Jian-xian Lin and Xiao-lai Zhou and Dan Dan Liang},
  journal={Ophthalmic research},
  year={2011},
  volume={45 4},
  pages={180-90}
}
PURPOSE Our aim was to establish a rat model of proliferative vitreoretinopathy (PVR) induced by macrophages and investigate whether macrophages can be a cell origin of fibroblast-like cells present in PVR. METHODS One eye of each rat received an intravitreal injection of macrophages. Clinical examination was performed to evaluate the development of PVR. Histological study was carried out to observe the pathological progression. Immunohistochemical staining with vimentin (VIM), glial… CONTINUE READING
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